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Mebendazole tablets (anthelmintic)

Recently discontinued from the US market (October 27, 2011); Teva Pharmaceuticals was the sole manufacturer for mebendazole and no statement for the discontinuation was provided.  Other anthelmintics (abendazole, ivermectin, praziquantel, pyrantel) are still available (no active shortages).

Mebendazole Indication	Alternative Treatment
Hookworm (A. duodenale, N. americanus)	1st line: Albendazole, pyrantel
Roundworm (A. lumbricoides)	1st line: Albendazole, pyrantel 2nd line: Nitazoxanide, ivermectin
Pinworm (E. vermicularis)	1st line: Albendazole, pyrantel 2nd line: Ivermectin
Whipworm (T. trichiura)	1st line: Albendazole 2nd line: Ivermectin
Capillariasis (C. phillipinensis; unlabeled use)	1st line: Albendazole
Giardiasis (G. duodenalis; unlabeled use)	1st line: Metronidazole, tinidazole, nitazoxanide 2nd line: Albendazole, paromomycin
Filarasis (M. perstans; unlabeled use)	1st line: Albendazole
Visceral larva migrans (Toxocariasis; unlabeled use)	1st line: Albendazole

Resources:

1.     American Society of Health-System Pharmacists. “Drug shortages: Discontinued Drugs.”  http://www.ashp.org/DrugShortages/NotAvailable/. Accessed April 22, 2012.

2.     American Society of Health-System Pharmacists. “Drug shortages: Current Drugs.”  http://www.ashp.org/DrugShortages/Current/. Accessed April 22, 2012.

3.     American Academy of Pediatrics.  Red Book: 2009 Report of the Committee on Infectious Diseases. 28^th Edition. Elk Grove Village, IL: American Academy of Pediatrics;2009.

4.     Wilson CM and Freedman DO. “Antiparasitic Agents.”  Principles and Practice of Pediatric Infectious Diseases. 3^rd Edition. Philidephia, PA:Elsevier, Inc.; 2008.